I mean... it wouldn't really surprise me that much at this point.
39
Corkyskog @sh.itjust.works - 1w
You can actually use Nalaxone as a base to make an opioid, I think Oxymorphone if I remember right.
24
dickalan @lemmy.world - 1w
Historical myth: The rumor started in the 1990s–2000s on drug forums (and later persisted on places like Reddit) because people noticed the close structural relationship and assumed “just swap the side chain.” In reality, pharmaceutical companies start from opium-derived precursors (thebaine → oxycodone → etc.) or full total synthesis — they never use naloxone as a starting material to make oxymorphone.
14
Corkyskog @sh.itjust.works - 1w
Well of course pharmaceutical companies don't, they can get cheaper base materials for opioids like the thebaine you mentioned. It was just someone proving it could be done and showing that it could be a potential concern one day. Right now it's a million times easier to get and cook fentanyl with precursors, so no one would bother with this synthesis. It's not like consumer nalaxone is cheap for the amount you get.
17
moody @lemmings.world - 1w
I dunno, I can go to the pharmacy right now and get naloxone for free if I wanted. They give that shit away here.
7
Corkyskog @sh.itjust.works - 1w
4 mg at a time... I think they might get suspicious after your 100th time.
And for the last 80 years, pharma has been making versions of opioids that are "less addictive", and MDs fall for it every time like rubes.
2
TonyTonyChopper - 1w
Walter White here. Organic chemistry can turn pretty much any molecule into a related molecule if you have enough time and patience. You want to purchase a precursor that's nearly the same as your desired product but also one that takes the fewest reactions to get there. I don't know how many reactions you would need to turn this into this but it's definitely possible.
https://d2cbg94ubxgsnp.cloudfront.net/Pictures/1024x536/7/2/8/140728_Naloxone-structure-vs-morphine.jpg
I almost wrote out a joking idea about mandatory injections of live, healthy viral cultures that all children are required to get for "natural, effective immune system development" but I didn't want to give the fuckers the idea.
5
NigelFrobisher @aussie.zone - 1w
We’re not laughing at you, America - we’re laughing with you!
5
D1re_W0lf - 1w
I misread “sarcasm” and was worried for a second.
5
🇰 🌀 🇱 🇦 🇳 🇦 🇰 🇮 - 1w
I thought that was a pack of smokes in his hand and the text was gonna say smoking is now good for you like in Sleeper.
fossilesque in science_memes
He was first to try it! :) So brave.
I mean... it wouldn't really surprise me that much at this point.
You can actually use Nalaxone as a base to make an opioid, I think Oxymorphone if I remember right.
Historical myth: The rumor started in the 1990s–2000s on drug forums (and later persisted on places like Reddit) because people noticed the close structural relationship and assumed “just swap the side chain.” In reality, pharmaceutical companies start from opium-derived precursors (thebaine → oxycodone → etc.) or full total synthesis — they never use naloxone as a starting material to make oxymorphone.
Well of course pharmaceutical companies don't, they can get cheaper base materials for opioids like the thebaine you mentioned. It was just someone proving it could be done and showing that it could be a potential concern one day. Right now it's a million times easier to get and cook fentanyl with precursors, so no one would bother with this synthesis. It's not like consumer nalaxone is cheap for the amount you get.
I dunno, I can go to the pharmacy right now and get naloxone for free if I wanted. They give that shit away here.
4 mg at a time... I think they might get suspicious after your 100th time.
A lot of opioids are fairly related, Oxycodone and Oxymorphone can be used as precursors to make Nalaxone and vice versa. I recall Four Thieves Vinegar Collective doing a similar trick though I don't remember what the actual precursor was.
And for the last 80 years, pharma has been making versions of opioids that are "less addictive", and MDs fall for it every time like rubes.
Walter White here. Organic chemistry can turn pretty much any molecule into a related molecule if you have enough time and patience. You want to purchase a precursor that's nearly the same as your desired product but also one that takes the fewest reactions to get there. I don't know how many reactions you would need to turn this into this but it's definitely possible. https://d2cbg94ubxgsnp.cloudfront.net/Pictures/1024x536/7/2/8/140728_Naloxone-structure-vs-morphine.jpg
Wouldn't that just be fentanyl?
https://feddit.nl/pictrs/image/cc01b391-5aac-4e1e-8acf-c81d356b7357.png
femtanyl mentioned
https://sh.itjust.works/pictrs/image/6e7daff2-b20b-40a1-8e40-220d1634d398.png
I almost wrote out a joking idea about mandatory injections of live, healthy viral cultures that all children are required to get for "natural, effective immune system development" but I didn't want to give the fuckers the idea.
We’re not laughing at you, America - we’re laughing with you!
I misread “sarcasm” and was worried for a second.
I thought that was a pack of smokes in his hand and the text was gonna say smoking is now good for you like in Sleeper.