You may ask yourself, "What is that beautiful house?"
You may ask yourself, "Where does that highway go to?"
And you may ask yourself, "Am I right? Am I wrong?"
And you may say to yourself, "My God! What have I done?"

By rebutting the false premises present in the question itself.

Yes

Both of the men had been trained for this moment, their lives had been a preparation for it, they had been selected at birth as those who would witness the answer, but even so they found themselves gasping and squirming like excited children.

"And you're ready to give it to us?" urged Loonsuawl.

"I am."

"Now?"

"Now," said Deep Thought.

They both licked their dry lips.

"All right," said the computer, and settled into silence again. The two men fidgeted. The tension was unbearable.

"You're really not going to like it," observed Deep Thought.

"Tell us!"

"All right," said Deep Thought. "The Answer to the Great Question..."

"Yes..!"

"Of Life, the Universe and Everything..." said Deep Thought.

"Yes...!"

"Is..." said Deep Thought, and paused.

"Yes...!"

"Is..."

"Yes...!!!...?"

"Forty-two," said Deep Thought, with infinite majesty and calm.